The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development - Archive ouverte HAL Access content directly
Journal Articles Journal of Affective Disorders Year : 2021

The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development

Camille Deforges
  • Function : Author
Suzannah Stuijfzand
  • Function : Author
Moira Robertson
  • Function : Author
Tone Breines Simonsen
  • Function : Author
Malin Eberhard-Gran
  • Function : Author
Susan Garthus-Niegel
  • Function : Author
Antje Horsch
  • Function : Author

Abstract

Background Posttraumatic Stress Disorder (PTSD) is a debilitating mental health disorder. Certain drugs, such as morphine and nitrous oxide gas (N2O), are administered to individuals who just experienced a traumatic event (e.g., soldiers, injured civilians). It is therefore crucial to understand if they incidentally affect PTSD symptom development. Furthermore, such observations could pave the way for the development of pharmacological prevention strategies of PTSD. Methods In this prospective population-based cohort study (n = 2,070), we examined the relationship between morphine or N2O administration during childbirth, and subsequent childbirth-related PTSD symptoms at eight weeks postpartum. Pain during labour, prior PTSD symptoms, and birth medical severity were included as covariates in the analyses. Results In women who developed PTSD symptoms, N2O administration during childbirth predicted reduced PTSD symptom severity (p < .001, small to medium effect size). A similar tendency was observed for morphine, but was not significant (p < .065, null to small effect size). Both drugs predicted increased PTSD symptoms when combined with severe pain during labour. Limitations This study was observational, thus drug administration was not randomised. Additionally, PTSD symptoms were self-reported. Conclusions Peritraumatic N2O administration may reduce subsequent PTSD symptom severity and thus be a potential avenue for PTSD secondary prevention. This might also be the case for morphine. However, the role of severe peritraumatic pain in context of drug administration deserves further investigation.

Dates and versions

hal-03972818 , version 1 (03-02-2023)

Identifiers

Cite

Camille Deforges, Suzannah Stuijfzand, Yvonnick Noël, Moira Robertson, Tone Breines Simonsen, et al.. The relationship between early administration of morphine or nitrous oxide gas and PTSD symptom development. Journal of Affective Disorders, 2021, 281, pp.557-566. ⟨10.1016/j.jad.2020.12.051⟩. ⟨hal-03972818⟩
0 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More